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Question about running speaker wire in walls.

I've read that running speaker wire parrallel with AC power lines in the walls is a not good and that even passing cross a power line perpendicular should even be avoided if possible. What if I have no choice but to run a speaker wire perpendicular with a power line? Is there anything I can do to help increase the shielding?

Also, what about other lines in the walls and ceilings, such as phone lines, or coax lines for cable television? Can speaker wire run parrallel or perpendicular with these types of lines?

And lastly, is is OK to run two speaker wires going to two different speakers parrallel along side each other in a wall?

BTW - I'm using 12 gauge CL-2 speaker wire from monoprice.