There's no indication of how long ago college was, so it's hard to gauge how old the current setup is. That might help answer some questions right away; if you got the system 2 years ago that's one answer, but it would be completely different if that was 10 years ago. And how old the equipment was before you bought it is also a factor. If you're in the process of upgrading why hold on to anything that's had years and years of use, and by more than one owner? Be that as it may...
If you're looking for a "significant difference" going from speakers with a 3.5 midrange to ones that use a 4" midrange probably won't do it. That's almost like-for-like, to be honest. You may be better served going a bit larger and considering things like the WaveCrest HVL-1. The subwoofers you're looking at are budget-oriented so they won't provide a huge difference in clarity/precision, but either of them will certainly have more output and depth. The sub upgrade will surely have a more noticeable difference than the Micca speakers you're considering.
Do you have a budget in mind? That will more than likely help you decide a bunch of things.
If you're looking for a "significant difference" going from speakers with a 3.5 midrange to ones that use a 4" midrange probably won't do it. That's almost like-for-like, to be honest. You may be better served going a bit larger and considering things like the WaveCrest HVL-1. The subwoofers you're looking at are budget-oriented so they won't provide a huge difference in clarity/precision, but either of them will certainly have more output and depth. The sub upgrade will surely have a more noticeable difference than the Micca speakers you're considering.
Do you have a budget in mind? That will more than likely help you decide a bunch of things.