If you want something very attractive, there's a few custom vent makers on the 'net that can make some really nice oak, maple, etc.. air vents...
My central A/C system at the old house had a very large vent, like 24" square... it wouldn't look out of place at all..
My central A/C system at the old house had a very large vent, like 24" square... it wouldn't look out of place at all..