I don't understand why people are still using MDF. Cabinet grade pine is about the same price, but half and weight(more important for car audio), twice the strength, and easier on blades. Birch is even stronger, but more expensive. Use good material and common sense, you won't have to go too crazy with bracing and multiple baffles.(I'm not saying don't brace at all)
Good luck with the build!
Good luck with the build!