Up or down is generally used for room acoustics. Close to, and aimed at a particular speaker is generally used for simulating anechoic response (speaker minus room acoustics). If you're going to use the 0-degree orientation, aim the mic between the speakers.
You don’t want to EQ based on a measurement from a generic calibration file, if that's what you have. You want an accurate graph for equalizing, and that requires a specific calibration file for the specific measurement mic used.
That’s a generic file. As you can see from the graph below, that is also posted on the page where you downloaded the file, response at the frequency extremes can vary several dB from one sample to the next.