First off, congrats.
Second, to answer your questions: You only need one wire per sub, so it really depends on where the subs are. If they are across the front, you can run one wire and split it at the wall jack. If they are spread out, I would run two, one to each location and split the signal at the source. Since you will have the walls open and RG6 is cheap, I'd run two anyways.
High surrounds are fine. Ideally, they should be a little above listening level (like 1 ft), but I've mounted them high before and customers have not noticed anything wrong. In fact most people like the movie surround (overhead) experience better than the behind you surround when the speakers are lower. I wouldn't sweat it.
Keep us posted on your build. My only advice would be to run conduit pipe (flexible orange or blue tube) to all your locations. That way if you need a data line, IR controller, extra speaker, or signal anywhere in the room, it's much easier in the future.
Good luck.
Second, to answer your questions: You only need one wire per sub, so it really depends on where the subs are. If they are across the front, you can run one wire and split it at the wall jack. If they are spread out, I would run two, one to each location and split the signal at the source. Since you will have the walls open and RG6 is cheap, I'd run two anyways.
High surrounds are fine. Ideally, they should be a little above listening level (like 1 ft), but I've mounted them high before and customers have not noticed anything wrong. In fact most people like the movie surround (overhead) experience better than the behind you surround when the speakers are lower. I wouldn't sweat it.
Keep us posted on your build. My only advice would be to run conduit pipe (flexible orange or blue tube) to all your locations. That way if you need a data line, IR controller, extra speaker, or signal anywhere in the room, it's much easier in the future.
Good luck.