Nicely put. :TI have a BSEE (Electrical Engineering) and one thing that cannot be overridden is Ohms Law! It's a simple concept. The larger the conductor diameter, the less resistance, therefore it can carry more current with less losses. This is true up to a point, then you reach a point of diminishing returns. The only way to get zero losses is to have a superconductor cooled to absolute zero temperature (not possible) so the closer you get to absolute zero, the less losses.
I (current) = V (voltage) / R (resistance)
So the less resistance, the more current passes through the conductor.
All this nonsense that made Monster Cable rich is bunk! If you use a 14AW (American Wire) gauge size wire instead of 18 gauge (zip cord), you will have less current losses. Most wire from the amp to the speakers are about 10ft. run. If you use a 16 or 14 gauge wire, it will have a minimal effect on this short of distance.
As far as the skin effect, it applies mostly to high frequency RF. I was a amateur radio operator and the skin effect starts taking into consideration in megahertz ranges. At audio frequencies, it absolutely has no effect! At higher frequencies (in megahertz and gigahertz range) electrons migrate towards the surface of the conductor, so the diameter of the conductor has a larger effect. This is why you see hollow tubes (called waveguides) used as conductors in the gigahertz range, such as radar. They are actually hollow, since there's no reason to have a center conductor in these frequency ranges.
As far as interconnect, "The Prof" is correct. All interconnects present a combination of inductance and capacitance called reactance, to the two units coupled with them. If anyone hears a difference, it's only because each cable has different reactance (capacitance and inductance) value which makes the amp or preamp sound different. It all depends what sound you favor as to what you hear, better or worse, it's just an opinion.
If you all remember the fairytale about the Emperors New Clothes: nobody wanted to admit he was naked for fear of other's thinking they are not knowledgeable.
My 50 years of knowledge of physics and electronics and common sense (not so common anymore) had saved me countless thousands of dollars over the years.
The final judge is what the music sound like compared to live source. Comparing it to another audio system is not valid because they all have colorization to the sound. It's just which one you prefer over the other, not which one is better or worse.